BioCluster

Central methodological contribution

Cluster stability

A representation with high external label alignment is not automatically the one whose clusters replicate across random seeds or survive modest image perturbation. This page reports both axes separately, deliberately without a single composite score.

PathMNIST (histopathology)

Stability-vs-utility frontier

Points in the upper-right are both stable and externally useful. A representation in the lower-right (stable but not useful) or upper-left (useful but unstable) is exactly the dissociation this project's central hypothesis (H3, see Methods) predicts may occur.

Seed-to-seed stability by algorithm

RepresentationAlgorithmkSeedsMean pairwise ARIMean pairwise NMI
PCA on pixelskmeans950.7670.851
PCA on pixelsgmm950.7610.816
Handcrafted color/texturekmeans950.9960.993
Handcrafted color/texturegmm950.8170.874
HOGkmeans950.3930.506
HOGgmm950.4490.581
ResNet50 (ImageNet-supervised)kmeans950.7470.812
ResNet50 (ImageNet-supervised)gmm950.6060.714
DINO ViT-S/16kmeans950.7200.823
DINO ViT-S/16gmm950.7240.829
DINOv2 ViT-S/14kmeans950.7970.864
DINOv2 ViT-S/14gmm950.6590.791

Perturbation robustness (cluster agreement)

Representationbrightnesscontrastcropnoiseblurcolor_jitter
PCA on pixels0.391.000.991.001.001.00
Handcrafted color/texture0.260.150.170.580.140.93
HOG1.001.000.990.931.001.00
ResNet50 (ImageNet-supervised)0.971.000.980.770.861.00
DINO ViT-S/161.001.000.980.960.651.00
DINOv2 ViT-S/140.991.000.980.970.891.00

Fraction of perturbed images assigned to the same cluster as their unperturbed original (1-NN proxy to the fitted k-means partition). Perturbations are modest, acquisition-plausible nuisance transforms only -- see Methods.

BloodMNIST (blood cell microscopy)

Stability-vs-utility frontier

Points in the upper-right are both stable and externally useful. A representation in the lower-right (stable but not useful) or upper-left (useful but unstable) is exactly the dissociation this project's central hypothesis (H3, see Methods) predicts may occur.

Seed-to-seed stability by algorithm

RepresentationAlgorithmkSeedsMean pairwise ARIMean pairwise NMI
PCA on pixelskmeans850.9270.926
PCA on pixelsgmm850.7350.810
Handcrafted color/texturekmeans850.8410.890
Handcrafted color/texturegmm850.9050.905
HOGkmeans850.5730.674
HOGgmm850.6200.686
ResNet50 (ImageNet-supervised)kmeans850.6720.758
ResNet50 (ImageNet-supervised)gmm850.6000.709
DINO ViT-S/16kmeans850.6840.750
DINO ViT-S/16gmm850.7120.786
DINOv2 ViT-S/14kmeans850.6400.708
DINOv2 ViT-S/14gmm850.6280.701

Perturbation robustness (cluster agreement)

Representationbrightnesscontrastcropnoiseblurcolor_jitter
PCA on pixels0.581.000.721.001.001.00
Handcrafted color/texture0.150.030.060.360.040.99
HOG1.001.000.991.001.001.00
ResNet50 (ImageNet-supervised)0.941.000.940.760.421.00
DINO ViT-S/160.991.000.980.930.691.00
DINOv2 ViT-S/140.971.000.940.940.591.00

Fraction of perturbed images assigned to the same cluster as their unperturbed original (1-NN proxy to the fitted k-means partition). Perturbations are modest, acquisition-plausible nuisance transforms only -- see Methods.